Antitrypanosomal Activities of Fluoroquinolones with Pyrrolidinyl Substitutions
AUTOR(ES)
Nenortas, Elizabeth
FONTE
American Society for Microbiology
RESUMO
Fluoroquinolones with pyrrolidinyl substitutions were tested against Trypanosoma brucei and mammalian cells. Bulky substituents at C-7 or a 1-2-bridging thiazolidine ring increased antitrypanosomal activity and selective toxicity. These compounds trap protein-DNA complexes and inhibit nucleic acid biosynthesis in trypanosomes, characteristics of topoisomerase II inhibition.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=182618Documentos Relacionados
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