Antinociceptive and antiinflammatory activities of the aqueous extract and isolated Cuphea carthagenensis (Jacq.) J. F. Macbr.

AUTOR(ES)

Fernandes, Francis Rigolo, Santos, André Luis dos, Arruda, Ana Maria Soares de, Vasques-Pinto, Luciana de Miranda C., Godinho, Rosely Oliveira, Torres, Luce Maria Brandão, Lapa, Antonio José, Souccar, Caden

FONTE

Revista Brasileira de Farmacognosia

DATA DE PUBLICAÇÃO

2002

RESUMO

The aqueous extract (AE) and isolated fraction (ppt-3) of Cuphea carthagenensis (Jacq.) J. F. Macbr (sete-sangrias) were tested using models of nociception and inflammation in mice. Oral administration (p.o.) of the AE (10 to 100 mg/kg) and fraction ppt-3 (0.1 to 10 mg/kg) reduced the acetic acid-induced writhing in mice by 40 to 50% and by 46 to 70% of control, respectively. At the same doses AE and ppt-3 did not affect the tail flick response. Fraction ppt-3 also reduced the carrageenininduced paw edema, but at a dose 1000 times higher than that inducing antinociception. The results indicated the presence in the plant of antinociceptive constituents devoid of antiinflammatory activity, with actions apparently mediated by non-opioid mechanisms.

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