Antinociceptive and anti-inflammatory effects of Caesalpinia pyramidalis in rodents
AUTOR(ES)
Santos, Cliomar A., Passos, Ailane M. P. R., Andrade, Fernando C., Camargo, Enilton A., Estevam, Charles S., Santos, Márcio R. V., Thomazzi, Sara M.
FONTE
Revista Brasileira de Farmacognosia
DATA DE PUBLICAÇÃO
30/09/2011
RESUMO
Caesalpinia pyramidalis Tul., Fabaceae, is a plant with an anti-inflammatory activity that is used in folk medicine. To evaluate the mechanism of action of this plant, studies were performed on its antinociceptive and anti-inflammatory properties using an ethanol extract (EE) made from the inner bark. Oral treatment of mice with the EE (100, 200, and 400 mg/kg) decreased their acetic acid-induced abdominal writhes (p<0.001) and their formalin-induced paw licking in both the first and second phases (p<0.001). This treatment increased the reaction time of mice on the hot-plate test (400 mg/kg, p<0.05); however, it did not alter their performance on the Rotarod performance test. The carrageenan-induced paw edema in the rats and the leukocyte migration into the peritoneal cavity of the mice were also reduced by the EE given at a dose of 400 mg/kg (p<0.05). In addition, the EE (100-400 mg/kg, v.o.) did not alter the arterial pressure of non-anesthetized rats. In conclusion, the EE of C. pyramidalis shows antinociceptive and anti-inflammatory activities in rodents, supporting the usage of this plant to treat various inflammatory diseases for which it has traditionally been used.
Documentos Relacionados
- In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovastatin in rodents
- Anti-inflammatory and anti-nociceptive effects of Zeyheria montana (Bignoniaceae) ethanol extract
- Anti-inflammatory and analgesic potential of Caesalpinia ferrea
- Antinociceptive and anti-inflammatory effects of a Geissospermum vellosii stem bark fraction
- Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study