Antinociceptive and anti-inflammatory activity of hydroalcoholic extracts and fractions from Erythrina mulungu
AUTOR(ES)
Oliveira, Mariana S. G. de, Aquino, Anansa B. de, Silva, Daniel L. da, Aquino, Pedro G. V., Santos, Mariana S., Porfírio, Anne P. R., Sant'Ana, Antônio E. G., Santos, Bárbara V. O., Alexandre-Moreira, Magna S., Araújo-Júnior, João X. de
FONTE
Revista Brasileira de Farmacognosia
DATA DE PUBLICAÇÃO
21/11/2011
RESUMO
Erythrina mulungu Mart. ex Benth., Fabaceae, popularly known as mulungu, is used for the treatment of insomnia and disorders of the central nervous system. This study examined the antinociceptive effects of the hydroalcoholic extracts (HAE), the ethyl acetate and chloroformic fractions from E. mulungu in four experimental models of nociception using laboratory mice. The extracts and fractions were administered orally to mice at doses of 100 mg/kg. Inhibition of abdominal contractions were observed for all the extracts and fractions tested, as compared to controls. All extracts and fractions from E. mulungu reduced the nociception activity produced by formalin in the 2nd phase. In the hot plate test no significant effect was observed for any extract or fraction. In the peritonitis test induced by Zymosan, all of the tested extracts and the chloroformic fraction, except for the ethyl acetate phase, reduced cell migration of the peritoneal cavity. We concluded that E. mulungu shows antinociceptive effects, which are independent of the opioid system.
Documentos Relacionados
- Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice
- Anti-inflammatory and antinociceptive activities of non-alkaloids fractions from Aconitum flavum in vivo
- Anti-inflammatory activity and chemical analysis of extracts from Trifolium riograndense
- Topical anti-inflammatory activity of yacon leaf extracts
- Anti-inflammatory activity of propolis extracts: a review