Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.

AUTOR(ES)

May, W S

RESUMO

The bryostatins are macrocyclic lactones, extracted from the marine bryozoan Bugula neritina, and have been reported to be potent antineoplastic agents. Results described here demonstrate that the bryostatins may also be useful as stimulators of normal human hematopoietic cells since they can (i) directly stimulate bone marrow progenitor cells to form colonies in vitro and (ii) functionally activate neutrophils. Structure-activity studies with bryostatin congeners indicate that these stimulatory properties may be dependent on the chain length and the unsaturated nature of the acylated group at carbons 20 and 7 of the bryostatin molecule. These stimulatory properties demonstrate that the naturally occurring bryostatins can mimic many of the biological effects of multipotential granulocyte-macrophage colony-stimulating factor. Thus, the coupling of antineoplastic activity with stimulatory growth properties for normal hematopoietic cells makes this agent an excellent probe to dissect the mechanism(s) of normal hematopoiesis. In addition, bryostatin may represent a clinically attractive agent useful for treating bone marrow failure states.

Documentos Relacionados

• Production of human glucocerebrosidase in mice after retroviral gene transfer into multipotential hematopoietic progenitor cells.
• Antithymocyte globulin stimulates human hematopoietic progenitor cells.
• Effect of acyclovir and interferon on human hematopoietic progenitor cells.
• Production of interleukin 1beta by human hematopoietic progenitor cells.
• Replication of Colorado tick fever virus within human hematopoietic progenitor cells.