Antimycobacterial Activity of Rifampin Under In Vitro and Simulated In Vivo Conditions

AUTOR(ES)

Stottmeier, K. D.

RESUMO

Minimal inhibitory concentrations of rifampin for different species of mycobacteria were determined in 7H-10 agar medium and Lowenstein-Jensen egg medium. When rifampin was incorporated into egg medium, approximately 90% of its activity was lost. The stability of rifampin was tested during storage at different temperatures and concentrations. When tested in agar medium, a combination of isoniazid (INH) and rifampin inhibited multiple drug-resistant strains of Mycobacterium intracellulare, but under simulated in vivo conditions the drugs did not eliminate these same organisms. Drug-resistant mutants of M. intracellulare multiplied during an 8-day period when exposed 10 hr daily to the INH-rifampin regimen. However, combinations of rifampin and INH reduced drug-resistant mycobacterial populations by 99%, an effect which could not be enhanced by the addition of either erythromycin, ethionamide, or cycloserine.

Documentos Relacionados

• Activity of amikacin against Mycobacterium avium complex under simulated in vivo conditions.
• In Vitro Antimycobacterial Activity of 5-Chloropyrazinamide
• Antimycobacterial activities in vitro and in vivo and pharmacokinetics of dihydromycoplanecin A.
• Degradation of orthodontic wires under simulated cariogenic and erosive conditions
• Uptake of azithromycin by various cells and its intracellular activity under in vivo conditions.