Antimalarial Quinones for Prophylaxis Based on a Rationale of Inhibition of Electron Transfer in Plasmodium*

AUTOR(ES)

Wan, Yieh-Ping

RESUMO

Knowledge of the biochemistry of Plasmodium is emerging as a new field. Previous studies showed that the parasite apparently requires electron transfer for energy, and techniques to study such energy mechanisms are available. The discovery of the existence of coenzyme Q8 in Plasmodium implies an indispensable functionality for this redox entity in the electron transfer of the parasite, as coenzyme Qn similarily functions in other forms of life.

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