Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus
AUTOR(ES)
Cabral, Rodrigo S., Sartori, Maura C., Cordeiro, Inês, Queiroga, Carmen L., Eberlin, Marcos N., Lago, João H. G., Moreno, Paulo R. H., Young, Maria C. M.
FONTE
Revista Brasileira de Farmacognosia
DATA DE PUBLICAÇÃO
29/11/2011
RESUMO
Conchocarpus fontanesianus (A. St.-Hill.) Kallunki & Pirani, Rutaceae, popularly known as pitaguará, is a native and endemic tree from São Paulo and Rio de Janeiro States, Brazil. Based in the information that anticholinesterasic derivatives could act as new prototypes to treatment of Alzheimer disease, this work describes the fractionation guided by evaluation of the anticholinesterase activity of the ethanolic stems extract from C. fontanesianus. This procedure afforded the alkaloids dictamnine (1), γ-fagarine (2), skimianine (3), and 2-phenyl-1-methyl-4-quinolone (4), as well as the coumarin marmesin (5).
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