Antibody-mediated neutralization of virus is abrogated by mycoplasma.
AUTOR(ES)
Dickson, C
RESUMO
The ability of a mouse mammary tumor cell line to abrogate antibody neutralization of vesicular stomatitis virus was shown to be due to the presence of mycoplasma. The mycoplasma was isolated from the cell line and typed as Mycoplasma orale. Colonies of this mycoplasma were used to deliberately infect cell cultures which then gained the capacity to reactivate antibody-neutralized virus. The extent of the reactivation depended on the source of neutralizing antiserum. Other species of mycoplasma were tested and were found to reactivate neutralized virus, indicating that this may be a general phenomenon of mycoplasma contamination.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=550999Documentos Relacionados
- Antibody-mediated neutralization in vivo of infectious papillomaviruses.
- Monoclonal antibody-mediated neutralization of infectious human papillomavirus type 11.
- Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization.
- Decreased metabolism and viability of Mycoplasma hominis induced by monoclonal antibody-mediated agglutination.
- Evidence that Antibody-Mediated Neutralization of Human Immunodeficiency Virus Type 1 by Sera from Infected Individuals Is Independent of Coreceptor Usage