Anti-snake venom effect of secodolastane diterpenes isolated from Brazilian marine brown alga Canistrocarpus cervicornis against Lachesis muta venom
AUTOR(ES)
Domingos, Thaisa Francielle S., Vallim, Magui Aparecida, Carvalho, Carla, Sanchez, Eladio Flores, Teixeira, Valéria Laneuville, Fuly, André Lopes
FONTE
Revista Brasileira de Farmacognosia
DATA DE PUBLICAÇÃO
01/04/2011
RESUMO
The effect of a Brazilian algae extract and also a mixture of two secodolastane diterpenes (linearol/isolinearol) that were isolated from the marine brown alga Canistrocarpus cervicornis were evaluated against biological activities of Lachesis muta snake venom. In vitro assays showed that the crude extract and the diterpenes were able to inhibit the clotting and proteolytic activity induced by L. muta crude venom, but not the hemolytic activity. However, only the diterpenes inhibited the hemolysis caused by a purified phospholipase A2 previously isolated from L. muta venom, denoted LM-PLA2-I. Interestingly, the crude algal extract and the diterpenes were able to protect mice from hemorrhage induced by L. muta venom. Thus, we may conclude that marine algae are rich and powerful sources of molecules that may be used against L. muta accidents in order to improve treatment of envenomation by this snake.
Documentos Relacionados
- Inhibitory effect of a Brazilian marine brown alga Spatoglossum schröederi on biological activities of Lachesis muta snake venom
- Uveitis following anti-snake venom therapy
- The red seaweed Plocamium brasiliense shows anti-snake venom toxic effects
- Anti-snake venom: use and adverse reaction in a snake bite study clinic in Bangladesh
- Pharmacological characterization of cnidarian extracts from the Caribbean Sea: evaluation of anti-snake venom and antitumor properties