Anti-schistosomiasis triterpene glycoside from the Egyptian medicinal plant Asparagus stipularis
AUTOR(ES)
El-Seedi, Hesham R., El-Shabasy, Rehan, Sakr, Hanem, Zayed, Mervat, El-Said, Asmaa M. A., Helmy, Khalid M. H., Gaara, Ahmed H. M., Turki, Zaki, Azeem, Muhammad, Ahmed, Ahmed M., Boulos, Loutfy, Borg-Karlson, Anna-Karin, Göransson, Ulf
FONTE
Revista Brasileira de Farmacognosia
DATA DE PUBLICAÇÃO
06/01/2012
RESUMO
Bioassay-guided isolation using an in vitro assay testing for anti- schistosomiasis yielded a novel triterpene saponin, asparagalin A, from the n-butanol extract of the roots of Asparagus stipularis Forssk., Asparagaceae. The structure was elucidated by spectroscopic analysis and chemical transformations. Administration of asparagalin A resulted in a retardation of worm growth and locomotion at the first day and showed a significant activity of egg-laying suppression at 200 µg/mL concentration.
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