Analyzing Gene-Frequency Data When the Effective Population Size Is Finite
AUTOR(ES)
Wilson, Susan R.
RESUMO
The statistical methods used by Schaffer, Yardley and Anderson (1977) and by Gibson et al. (1979) to analyze the variation in allele frequencies in two common types of experimental procedure, where the effective population size is finite, are extended to a more general situation involving a greater range of experiments. The analysis developed is more sensitive in detecting changes in allele frequency due to both fluctuating and balancing selection, as well as to directional selection. The error involved in many studies due to ignoring the effective population size structure would appear to be large. The range of hypotheses that can be considered may be increased as well. Finally, the method of determining bounds for the effective population size, when a particular genetic model is known to hold for a data set, is also outlined.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1214242Documentos Relacionados
- Dynamics of the Linkage Disequilibrium Function under Models of Gene-Frequency Hitchhiking
- A New Method for Estimating the Effective Population Size from Allele Frequency Changes
- Genetic variability and effective population size when local extinction and recolonization of subpopulations are frequent
- A Generalized Approach for Estimating Effective Population Size from Temporal Changes in Allele Frequency
- The Effective Size of a Subdivided Population