Analytical methods for vancomycin determination in biological fluids and in pharmaceuticals
AUTOR(ES)
Vila, Marta Maria Duarte Carvalho, Oliveira, Robson Machado de, Gonçalves, Marcos Moisés, Tubino, Matthieu
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2007-04
RESUMO
Vancomycin is a glycopeptide antibiotic employed in the treatment of infections caused by certain methicillin-resistant staphylococci. It is indicated also for patients allergic to penicillin or when there is no response to penicillins or cephalosporins. The adequate vancomycin concentration levels in blood serum lies between 5 and 10 mg/L. Higher values are toxic, causing mainly nephrotoxicity and ototoxicity. Various analytical methods are described in the literature: spectrophotometric, immunologic, biologic and chromatographic methods. This paper reviews the main analytical methods for vancomycin determination in biological fluids and in pharmaceutical preparations.
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