"Análise da sensibilidade e reprodutibilidade da escala de Basso, Beattie e Bresnahan (BBB) em ratos Wistar" / Analysis of sensitivity and reproducibility of the Basso,Beattie and Bresnahan (BBB) Scale on rats

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

An assessment of the sensitivity and reproducibility of the Basso, Beattie and Bresnahan functional scale (BBB scale) was carried out, to evaluate the locomotion capacity following spinal cord injury. The BBB scale is a predictive procedure based on specific observational criteria of the locomotion of the animal under way, which attributes a sequential and cumulative score corresponding to satisfied pre-established criteria. 30 Wistar rats underwent laminectomy and light, moderate and severe spinal cord injury generated by the computerized equipment of impact through weight-drop developed by the University of New York (NYU Weight-Drop Impactor). At day 28 following the spinal cord injury, each rat was placed into a transparent box (80x80x30cm), with the bottom and the posterior wall lined with dark anti-slip material, and stimulated to move. The locomotion of each rat was recorded, simultaneously, by 3 digital cameras and, after editing, identical copies of the films were sent to six independent researchers, with no information regarding the severity of the injure in each rat, for determining the locomotory capabilities according to the Basso, Beattie and Bresnahan scale. The sensitivity of the method was verified for detecting differences between the results obtained from the left and right-side paws, among the rats subjected to light, moderate and severe injuries and among the evaluators through comparisons of the functional results and the reproducibility through correlation tests.

ASSUNTO(S)

spine métodos recuperação de função fisiológica ratos rats escalas coluna vertebral methods spine injuries scales recovery of function traumatismos da coluna vertebral

ACESSO AO ARTIGO

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