Análise Comparativa dos Efeitos da Combinação Fumarato de Formoterol e Brometo de Tiotrópio versus Monoterapia com Fumarato de Formoterol na Hiperinsuflação Pulmonar Dinâmica e na Tolerância ao Exercício em Pacientes com Doença Pulmonar Obstrutiva Crônica Moderada à Grave / Effects of Formoterol versus Formoterol plus Tiotropium on Exercise Tolerance in COPD

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

27/02/2009

RESUMO

It is currently unclear whether the additive effects of a combination between a longacting b2-agonist and the antimuscarinic tiotropium bromide (TIO) on lung function are actually translated into higher exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). On a double-blind and cross-over study, 33 patients with moderate to severe disease (FEV1= 47.4 12.9 % pred) were randomly allocated to formoterol fumarate 12 ìg b.i.d. (FOR) plus TIO 18 ìg o.d. or FOR plus placebo o.d. during 2 weeks. Cardiopulmonary responses were evaluated on constant-speed treadmill tests to the limit of tolerance (Tlim). Increases in FEV1 were greater with FOR-TIO compared to FOR (p<0.05). Although FOR-TIO was associated with larger mean group improvements in Tlim and dynamic hyperinflation, there was a lack of additional effect of TIO over FOR in 10/26 (38.4 %) patients. Of note, those who further improved with FOR-TIO had worse baseline exercise capacity and airways obstruction; in addition, they had larger increases in FEV1 (p<0.05) and inspiratory capacity (p= 0.09) at the end of treatment with the combination therapy. In conclusion, FOR-TIO further enhances exercise tolerance compared to FOR monotherapy in selected COPD patients who are particularly disabled and functionally responsive to cholinergic blockade.

ASSUNTO(S)

exercício hiperinsuflação pulmonar pneumologia broncodilatador dispnéia dpoc

ACESSO AO ARTIGO

Documentos Relacionados