An upstream repressor element plays a role in Igf2 imprinting

AUTOR(ES)

Eden, Sharon

FONTE

Oxford University Press

RESUMO

The imprinted Igf2 gene is associated with a small upstream region that is differentially methylated on the active paternal allele. We have identified a repressor element within this sequence and shown that repression is probably mediated through a trans- acting factor, GCF2. DNA methylation of this site abrogates both protein binding and repressor activity. Targeting experiments demonstrate that this element plays a role in the repression of the maternal Igf2 gene in vivo.

Documentos Relacionados

• Genomic Imprinting Controls Matrix Attachment Regions in the Igf2 Gene
• Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2
• Enhancer competition between H19 and Igf2 does not mediate their imprinting
• Igf2 imprinting does not require its own DNA methylation or H19 RNA
• Tandem Repeat Hypothesis in Imprinting: Deletion of a Conserved Direct Repeat Element Upstream of H19 Has No Effect on Imprinting in the Igf2-H19 Region†