An Efficient and Chemoselective Deprotection of Aryl tert-Butyldimethylsilyl (TBDMS) Ethers by NaCN
AUTOR(ES)
Qiao, Xue-jun, Hou, Xiao, Fang, Wu-hong, Bao, Xue-fei, Chen, Guo-liang
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2016-05
RESUMO
Phenolic tert-butyldimethylsilyl (TBDMS) ethers can be deprotected to yield phenols in excellent yield using sodium cyanide (NaCN) as catalyst in ethanol. The deprotectation of various phenolic TBDMS ethers were found to be very convenient, fast, high yielding and chemoselective.
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