Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?

AUTOR(ES)

Isaacs, Jeremy D

FONTE

BMJ Group

RESUMO

Sensory involvement is thought not to be a feature of amyotrophic lateral sclerosis (ALS). However, in the setting of a specialist motor neuron disease clinic, we have identified five patients with sporadic ALS and a sensory neuropathy for which an alternative cause could not be identified. In three individuals, sensory nerve biopsy was performed, demonstrating axonal loss without features of an alternative aetiology. These findings support the hypothesis that ALS is a multisystem neurodegenerative disorder that may occasionally include sensory neuropathy among its non‐motor features.

Documentos Relacionados

• Generalised sensory system abnormalities in amyotrophic lateral sclerosis: a European multicentre study
• Amyotrophic Lateral Sclerosis
• Prognosis of amyotrophic lateral sclerosis with respiratory onset
• Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis–frontotemporal dementia phenotypes
• Misdiagnoses in a Brazilian population with amyotrophic lateral sclerosis