Amino acid substitutions in inherited albumin variants from Amerindian and Japanese populations.
AUTOR(ES)
Takahashi, N
RESUMO
We report an effort to determine the basis for the altered migration of seven inherited albumin variants detected by one-dimensional electrophoresis in population surveys involving tribal Amerindians and Japanese children. An amino acid substitution has thus far been determined for four of the variants. The randomness in the albumin polypeptide of these and the other sixteen independently ascertained amino acid substitutions of albumin and proalbumin thus far established was analyzed; the clustering of eight of these at two positions in the six-amino acid propeptide sequence seems noteworthy. By comparison with other proteins studied by electrophoresis, albumin exhibits "average" variability. It is a paradox that individuals who, for genetic reasons, lack albumin exhibit no obvious ill effects; yet, electrophoretic variants of albumin are no more numerous than are variants of proteins, the absence of which results in severe disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=299464Documentos Relacionados
- Identical structural changes in inherited albumin variants from different populations.
- Amino acid substitutions in albumin variants found in Brazil.
- Amino acid substitutions in genetic variants of human serum albumin and in sequences inferred from molecular cloning.
- Point substitutions in albumin genetic variants from Asia.
- Genetic variants of serum albumin in Americans and Japanese.