AMERICAN CUTANEOUS LEISHMANIASIS WITH UNUSUAL CLINICAL PRESENTATION AND RESPONSE TO TREATMENT

AUTOR(ES)

FERNANDES, Andrea Claudia Bekner Silva, PEDROSO, Raíssa Bocchi, VENAZZI, Eneide Aparecida Sabaini, ZANZARINI, Paulo Donizeti, ARISTIDES, Sandra Mara Alessi, LONARDONI, Maria Valdrinez Campana, SILVEIRA, Thaís Gomes Verzignassi

FONTE

Rev. Inst. Med. trop. S. Paulo

DATA DE PUBLICAÇÃO

22/03/2016

RESUMO

The clinical manifestations and prognosis of cutaneous leishmaniasis (CL) can be influenced by the immune response of the patient and the species of the parasite. A case of atypical clinical presentation of CL, with development of non-characteristic lesions, poor response to therapy, and a long time to resolution is reported. Confirmatory laboratory tests included parasite detection, indirect immunofluorescence, Montenegro skin test, polymerase chain reaction, and parasite identification by multilocus enzyme electrophoresis. The parasite was identified as Leishmaniabraziliensis. The lesion was unresponsive to three complete courses of N-methylglucamine antimoniate intramuscular, and to treatment with pentamidine. The patient did not tolerate amphotericin B. The lesion finally receded after treatment with intravenous N-methylglucamine antimoniate. It is essential to ensure the accuracy of diagnosis and the appropriate treatment, which can include the use a second choice drug or a different route of administration.

Documentos Relacionados

• Clinical and epidemiological aspects of American cutaneous leishmaniasis with genital involvement,
• Immunophenotypic characterization of patients with American cutaneous leishmaniasis prior to and after treatment in Pernambuco, Brazil
• Immunochemotherapy in American cutaneous leishmaniasis: immunological aspects before and after treatment
• Antibodies to laminin in American cutaneous leishmaniasis.
• Clinical and immunopathological spectrum of American cutaneous leishmaniasis with special reference to the disease in Amazonian Brazil: a review