Alzheimer-like neurotransmitter deficits in adult Down's syndrome brain tissue.
AUTOR(ES)
Godridge, H
RESUMO
Brain tissue taken at necropsy from five cases of Down's syndrome and six controls was analysed for changes in neurotransmitter markers. Concentrations of noradrenaline (NA), dopamine (DA) and its major metabolite homovanillic acid (HVA), 5-hydroxytryptamine (5HT) and its metabolite 5-hydroxyindoleacetic acid (5HIAA) were determined by means of HPLC, whilst choline acetyltransferase (ChAT) was measured by a radiochemical technique. Significant reductions in NA, 5HT and ChAT were found in most cortical and subcortical regions of the Down's syndrome tissue investigated. The neuropathological lesions were assessed using a fluorescent stain for neuritic plaques and neurofibrillary tangles. These were present to varying extents in every Down's syndrome case except the youngest but were not found in control tissue of comparable age. The results indicate profound transmitter deficits and neuropathological abnormalities in adult patients with Down's syndrome, which closely resemble those of Alzheimer's disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1032086Documentos Relacionados
- Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis
- Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice
- Dopaminergic neurotransmitter systems in Alzheimer's disease and in Down's syndrome at middle age.
- Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.
- Alzheimer's Disease and Down's Syndrome