Alopecia secondary to anti-tumor necrosis factor-alpha therapy

AUTOR(ES)

Ribeiro, Lara Beatriz Prata, Rego, Juliana Carlos Gonçalves, Estrada, Bruna Duque, Bastos, Paula Raso, Piñeiro Maceira, Juan Manuel, Sodré, Celso Tavares

FONTE

An. Bras. Dermatol.

DATA DE PUBLICAÇÃO

2015-04

RESUMO

Biologic drugs represent a substantial progress in the treatment of chronic inflammatory immunologic diseases. However, its crescent use has revealed seldom reported or unknown adverse reactions, mainly associated with anti-tumor necrosis factor (anti-TNF). Psoriasiform cutaneous reactions and few cases of alopecia can occur in some patients while taking these drugs. Two cases of alopecia were reported after anti-TNF therapy. Both also developed psoriasiform lesions on the body. This is the second report about a new entity described as 'anti-TNF therapy-related alopecia', which combines clinical and histopathological features of both alopecia areata and psoriatic alopecia. The recognition of these effects by specialists is essential for the proper management and guidance of these patients.

Documentos Relacionados

• Differential inhibition of lipopolysaccharide-induced phenomena by anti-tumor necrosis factor alpha antibody.
• Effect of anti-tumor necrosis factor alpha antibodies on histopathology of primary Salmonella infections.
• Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein.
• Anti-endotoxin monoclonal antibodies inhibit secretion of tumor necrosis factor-alpha by two distinct mechanisms.
• Remission of Behcet's disease with anti-tumor necrosis factor monoclonal antibody therapy: a case report