Allopurinol treatment and its effect on renal function in gout: a controlled study.
AUTOR(ES)
Gibson, T
RESUMO
Fifty-nine patients with primary gout were treated with either a combination of colchicine and allopurinol or colchicine alone. Assessments of renal function over 2 years revealed a statistically significant fall of glomerular filtration rate an urine concentrating ability in those receiving only colchicine. The renal function of patients given allopurinol did not change. Treatment with allopurinol resulted ina significant reduction of ammonium excretion, a phenomenon which could not be readily explained. Urate clearance also declined during allopurinol treatment, and the impaired urate clearance associated with gout became more evident. The most important observation was that allopurinol retarded an apparent decline of renal function. Presumably this was achieved through its hypouricaemic effect and implies that the hyperuricaemia of gouty patients is deleterious to the kidneys.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1000865Documentos Relacionados
- Allopurinol effect on renal function in gout.
- Migration and gout: the Tokelau Island migrant study.
- Frequency of chondrocalcinosis of the knees and avascular necrosis of the femoral heads in gout: a controlled study.
- High‐resolution ultrasonography of the first metatarsal phalangeal joint in gout: a controlled study
- Cardiovascular disease and gout: a function of sex and age?