Alkaloids and triterpene from Almeidea coerulea (Nees and Mart.) a. St.-Hil. and anti-leishmanial activity

AUTOR(ES)

Cortez, Lucia Elaine Ranieri, Ferreira, Izabel Cristina Piloto, Lonardoni, Valdrinez Campana, Ferreira, Antonio Gilberto, Vieira, Paulo Cesar, Silva, Maria Fátima das Graças Fernandes da, Fernandes, João Batista, Cortez, Diógenes Aparicio Garcia

FONTE

Brazilian Archives of Biology and Technology

DATA DE PUBLICAÇÃO

2011-02

RESUMO

The dichloromethane extract of Almeidea coerulea stems yielded the (11-hydroxyrutaecarpine alkaloid reported for the first time from this species) and the triterpene (28-hydroxy-28, 29-dihydrolupeol). The dictamine, skimianine, sitosterol and stigmasterol were also isolated from methanol extract. Extracellular forms of Leishmania amazonensis (promastigotes) was tested with dichloromethane extract and 28-hydroxy-28, 29-dihydrolupeol with showed anti-leishmanial activity above 0.1 mg/mL and 75µg/mL (inhibited 50% promastigote growth), respectively.

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