Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease

AUTOR(ES)

Summer, Ross

FONTE

American Physiological Society

RESUMO

Adiponectin (APN) is an adipocyte-derived factor that exists at high concentrations in serum and has anti-inflammatory and systemic vascular-protective properties. In this study, we investigated the role of APN in pulmonary vascular homeostasis. We found that APN localizes to the luminal side of blood vessels in lung and acts in vitro to block TNF-α-induced E-selectin upregulation in pulmonary artery endothelial cells. Targeted deletion of the APN gene in mice leads to a vascular phenotype in lung characterized by E-selectin upregulation and age-dependent increases in perivascular inflammatory cell infiltration and pulmonary arterial pressures. Taken together, these findings demonstrate an important role for APN in lung vascular homeostasis and suggest that APN-deficient states may contribute to the pathogenesis of inflammatory pulmonary vascular disease and to the development of pulmonary hypertension.

Documentos Relacionados

• Pulmonary vascular reactivity in severe pulmonary hypertension associated with mixed connective tissue disease.
• Adiponectin Deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling
• Pulmonary artery banding in congenital heart disease associated with pulmonary hypertension
• C1r deficiency: an inborn error associated with cutaneous and renal disease
• Angiotensin converting enzyme activity and evolution of pulmonary vascular disease in rats with monocrotaline pulmonary hypertension.