Adaption to Hyperoxia: INFLUENCE ON PROTEIN SYNTHESIS BY LUNG AND ON GRANULAR PNEUMOCYTE ULTRASTRUCTURE
AUTOR(ES)
Massaro, Gloria D.
RESUMO
We studied the influence of prolonged exposure to hyperoxia (O2 > 98%) on protein synthesis and on the ultrastructure of the granular pneumocyte. To study protein synthesis, as indicated by l-[U-14C]-leucine incorporation into protein, lung slices were incubated with radioactive leucine and a surface-active fraction was obtained by ultracentrifugation of lung homogenates. We found that, following an initial depression in protein synthesis after 48 h of hyperoxia, protein synthesis in rats exposed to oxygen for 96 h rose to greater than control levels. This increase in protein synthesis was noted in whole lung protein and in protein present in the surface-active fraction.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=333050Documentos Relacionados
- Hyperoxia: Influence on Lung Mechanics and Protein Synthesis
- Hyperoxia: A Stereologic Ultrastructural Examination of Its Influence on Cytoplasmic Components of the Pulmonary Granular Pneumocyte
- Alterations of the Thioredoxin System by Hyperoxia: Implications for Alveolar Development
- Effect of postnatal malnutrition on hyperoxia-induced newborn lung development
- Tolerance of rats to hyperoxia. Lung antioxidant enzyme gene expression.