Acute HIV infection with rapid progression to AIDS
AUTOR(ES)
Silva, Marcio de Oliveira, Bastos, Milena, Martins Netto, Eduardo, Gouvea, Nancy Alves de Lima, Torres, Alex Jose Leite, Kallas, Esper, Watkins, David I, Altfeld, Marcus, Brites, Carlos
FONTE
Brazilian Journal of Infectious Diseases
DATA DE PUBLICAÇÃO
2010-06
RESUMO
Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable.
Documentos Relacionados
- Slow progression to AIDS in intravenous drug users infected with HIV in Norway.
- Open lung biopsy for investigation of acute respiratory episodes in patients with HIV infection and AIDS.
- Selection for Human Immunodeficiency Virus Type 1 Recombinants in a Patient with Rapid Progression to AIDS
- Care for patients with HIV infection and AIDS.
- Purchasing care for people with HIV infection and AIDS.