Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation

AUTOR(ES)

Duman, Hatice, Topal, Ilteris Oguz, Kocaturk, Emek, Cure, Kubra, Mansuroglu, Ilknur

FONTE

An. Bras. Dermatol.

DATA DE PUBLICAÇÃO

2017-06

RESUMO

Abstract Acute generalized exanthematous pustulosis is a rare drug-induced eruption that is characterized by acute, nonfollicular sterile pustules on an erythematous and edematous base. The most frequently implicated drugs are beta-lactam antibiotics. Hydroxychloroquine has been widely used to treat dermatologic and rheumatologic diseases and has been reported as a rare cause of acute generalized exanthematous pustulosis. A 42-year-old female presented with pustular lesions on the skin surface with erythema, facial edema, and occasional atypical target-like lesions after 21 days of treatment with 200mg/day hydroxychloroquine for rheumatoid arthritis, diagnosed one month previously. We report a case with acute generalized exanthematous pustulosis induced by hydroxychloroquine and treated with dapsone and systemic corticosteroid.

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