Activity of topoisomerase inhibitors against Pneumocystis carinii in vitro and in an inoculated mouse model.

AUTOR(ES)

Fishman, J A

RESUMO

Five topoisomerase II inhibitors (amsacrine [m-AMSA], two epipodophyllotoxins, and two quinolones) and the alkaloid camptothecin (a topoisomerase I inhibitor) were evaluated to assess their activities against Pneumocystis carinii. In vitro, both etoposide (VP-16) and teniposide (VM-26) at 1 microgram/ml suppressed P. carinii growth. Amsacrine was toxic to P. carinii and to the feeder cells in vitro. Camptothecin suppressed the growth of P. carinii in vitro only at 100 micrograms/ml. Studies in immunosuppressed mice demonstrated the efficacy of teniposide against P. carinii pneumonia, but successful administration of teniposide was schedule dependent with significant toxicity at therapeutic dosages.

Documentos Relacionados

• Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection.
• Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo.
• In vitro activities of acridone alkaloids against Pneumocystis carinii.
• Activity of inosine analogs against Pneumocystis carinii in culture.
• In Vitro and In Vivo Effects of Quinupristin-Dalfopristin against Pneumocystis carinii