Activity of selenazofurin against influenza A and B viruses in vitro.

AUTOR(ES)

Sidwell, R W

RESUMO

Activity of the new antiviral compound selenazofurin was compared with the known active compounds ribavirin and amantadine against influenza A and B viruses. In experiments with Madin Darby canine kidney cells, selenazofurin inhibited the cytopathic effect and yield of influenza A/NWS/33 virus, with 50% effective dose ranges of 0.7 to 1.4 micrograms/ml (virus rating [VR], 1.3 to 1.4). The 50% effective dose range for ribavirin was 1.2 to 1.6 micrograms/ml (VR, 1.0 to 1.3), and for amantadine it was 9 micrograms/ml (VR, 0.9). Selenazofurin and ribavirin were similarly inhibitory to influenza B/Lee/40 virus, whereas amantadine was inactive. Selenazofurin appeared somewhat cytotoxic in these studies at concentrations as low as 1 micrograms/ml.

Documentos Relacionados

• Comparative activities of several nucleoside analogs against influenza A, B, and C viruses in vitro.
• Effects of selenazofurin and ribavirin and their 5'-triphosphates on replicative functions of influenza A and B viruses.
• In Vitro Effect of Virazole Against Influenza Viruses
• Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets.
• Mutational analysis of influenza B virus RNA transcription in vitro.