Activity of Brazilian and Bulgarian propolis against different species of Leishmania
AUTOR(ES)
Machado, Gérzia Maria de Carvalho, Leon, Leonor Laura, Castro, Solange Lisboa de
FONTE
Memórias do Instituto Oswaldo Cruz
DATA DE PUBLICAÇÃO
2007-02
RESUMO
Extracts of propolis samples collected in Brazil and Bulgaria were assayed against four Leishmania species - Leishmania amazonensis, L. braziliensis, L. chagasi from the New World, and L. major from the Old World - associated to different clinical forms of leishmaniasis. The composition of the extracts has been previously characterized by high temperature high resolution gas chromatography coupled to mass spectrometry. Considering the chemical differences among the extracts and the behavior of the parasites, it was observed significant differences in the leishmanicidal activities with IC50/1 day values in the range of 2.8 to 229.3 µg/ml . An overall analysis showed that for all the species evaluated, Bulgarian extracts were more active than the ethanol Brazilian extract. As the assayed propolis extracts have their chemical composition determined it merits further investigation the effect of individual components or their combinations on each Leishmania species.
Documentos Relacionados
- The effect of Bulgarian propolis against Trypanosoma cruzi and during its interaction with host cells
- Effects of Brazilian propolis on Leishmania amazonensis
- Chemical composition and antibacterial activity of Brazilian propolis essential oil
- Chemical and cytotoxic analyses of three varieties of Brazilian propolis (green propolis, jataí propolis and brown propolis) and its anti-Sporothrix brasiliensis in vitro activity
- Activity of Fabaceae species extracts against fungi and Leishmania: vatacarpan as a novel potent anti-Candida agent