Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons

AUTOR(ES)

Dubchak, Inna

FONTE

Cold Spring Harbor Laboratory Press

RESUMO

Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human–mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.

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