Activation of SoxR by Overproduction of Desulfoferrodoxin: Multiple Ways To Induce the soxRS Regulon
AUTOR(ES)
Gaudu, Philippe
FONTE
American Society for Microbiology
RESUMO
The soxRS response, which protects cells against superoxide toxicity, is triggered by the oxidation of SoxR, a transcription factor. Superoxide excess and NADPH depletion induce the regulon. Unexpectedly, we found that the overproduction of desulfoferrodoxin, a superoxide reductase from sulfate-reducing bacteria, also induced this response. We suggest that desulfoferrodoxin interferes with the reducing pathway that keeps SoxR in its inactive form.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=94477Documentos Relacionados
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