Activation of cells in the anterior pretectal nucleus by dorsal column stimulation in the rat.
AUTOR(ES)
Rees, H
RESUMO
1. The responses of neurones in the anterior pretectal nucleus (APTN) to electrical stimulation of the dorsal columns at twice the threshold for A fibres were studied in the rat anaesthetized with urethane. 2. APTN cells were excited by dorsal column stimulation. Forty-six discharged phasically in response to a single stimulus. Sixteen cells did not respond phasically but slowly increased the discharge rate with repeated stimulation. 3. Electrical stimulation of the contralateral gracile fasciculus caused neurones in the APTN to discharge with a variable latency of 2-22 ms. Stimulations of the ipsilateral gracile and contralateral cuneate fasciculi had weaker effects. 4. Microinjection of DL-homocysteic acid into the contralateral gracile nucleus increased the discharge rate of APTN neurones. Microinjection of gamma-aminobutyric acid into the contralateral gracile nucleus blocked the gracile fasciculus evoked excitation of APTN neurones. 5. On thirteen occasions cells in the gracile nucleus were driven antidromically by electrical stimulation of the APTN. 6. It is concluded that electrical stimulation of the gracile fasciculus activates a monosynaptic excitatory input to the APTN.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1189271Documentos Relacionados
- Antinociceptive effects of dorsal column stimulation in the rat: involvement of the anterior pretectal nucleus.
- Anterior pretectal stimulation alters the responses of spinal dorsal horn neurones to cutaneous stimulation in the rat.
- Anterior pretectal nucleus facilitation of superficial dorsal horn neurones and modulation of deafferentation pain in the rat.
- Electrical stimulation of the salivatory nucleus in the rat.
- Localization in the dorsal motor nucleus of the vagus in the rat.