Action potential propagation in mitral cell lateral dendrites is decremental and controls recurrent and lateral inhibition in the mammalian olfactory bulb

AUTOR(ES)

Margrie, Troy W.

FONTE

The National Academy of Sciences

RESUMO

In the mammalian main olfactory bulb (MOB), the release of glutamate from lateral dendrites of mitral cells onto the dendrites of granule cells evokes recurrent and lateral inhibition of mitral cell activity. Whole-cell voltage recordings in the mouse MOB in vivo and in vitro show that recurrent and lateral inhibition together control the number, duration, and onset of odor-evoked action potential (AP) firing in mitral cells. APs in mitral cells propagate into the lateral dendrites and evoke a transient increase in dendritic calcium concentration ([Ca2+]), which is decremental with distance from the soma, and increases with AP number. These results suggest that the extent of AP propagation in lateral dendrites of mitral cells, along with the concomitant dendritic Ca2+ transient, controls the amplitude of lateral and recurrent inhibition and thus is a critical determinant of odor-specific AP patterns in the MOB.

Documentos Relacionados

• Action potential propagation into the presynaptic dendrites of rat mitral cells.
• Analysis of a long-duration inhibitory potential in mitral cells in the isolated turtle olfactory bulb.
• Electrophysiological analysis of mitral cells in the isolated turtle olfactory bulb.
• Calcium buffering in rodent olfactory bulb granule cells and mitral cells
• Calcium Signaling in Mitral Cell Dendrites of Olfactory Bulbs of Neonatal Rats and Mice During Olfactory Nerve Stimulation and β-Adrenoceptor Activation