Action of nonsteroidal, anti-inflammatory drugs on human and rat peripheral leucocyte migration in vitro.
AUTOR(ES)
Brown, K A
RESUMO
Using an in vitro system of cell migration from glass capillary tubes, the nonsteroidal, anti-inflammatory agents sodium salicylate, aspirin, ibuprofen, phenylbutazone, and indomethacin were shown to inhibit the migration of human peripheral leucocytes in a dose-related manner. This drug action was not confined to one species, as shown by the modification of rat peripheral leucocyte motility by sodium salicylate and aspirin. The relevance of the human findings to the clinical effectiveness of these agents is discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1006672Documentos Relacionados
- Effect of some anti-inflammatory drugs on fibroblast-leucocyte interaction in vitro.
- Nonsteroidal anti-inflammatory drugs and ulcers.
- Hepatitis and non-steroidal anti-inflammatory drugs.
- Gastrointestinal complications of nonsteroidal anti-inflammatory drugs.
- Nonsteroidal Anti-inflammatory Drugs: Mechanisms and Clinical Use
