Acid-Base Alterations and Renal Gluconeogenesis: Effect of pH, Bicarbonate Concentration, and PCO2*
AUTOR(ES)
Kamm, Donald E.
RESUMO
In previous studies it was found that renal cortical slices from rats with induced metabolic acidosis have an increased capacity to produce glucose, whereas cortical slices from rats with metabolic alkalosis manifest decreased gluconeogenesis. To evaluate the relative influence of extracellular fluid pH, [HCO3-], and carbon dioxide tension on renal gluconeogenesis, we observed glucose production by cortex from rats with induced respiratory acidosis, and by cortex taken from normal animals and incubated in acid and alkaline media.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=297116Documentos Relacionados
- pH and Bicarbonate Effects on Mitochondrial Anion Accumulation: PROPOSED MECHANISM FOR CHANGES IN RENAL METABOLITE LEVELS IN ACUTE ACID-BASE DISTURBANCES
- Bicarbonate Uptake by Nitrifiers: Effects of Growth Rate, pH, Substrate Concentration, and Metabolic Inhibitors
- Measurement of pH, PCO2, and standard bicarbonate on samples of capillary blood
- Intracellular Acid-Base Regulation. II. The Interaction between CO2 Tension and Extracellular Bicarbonate in the Determination of Muscle Cell pH *
- The role of pH, PCO2, and bicarbonate in regulating rat diaphragm citrate content