Accounting for Unmeasured Population Substructure in Case-Control Studies of Genetic Association Using a Novel Latent-Class Model
AUTOR(ES)
Satten, Glen A.
RESUMO
We propose a novel latent-class approach to detect and account for population stratification in a case-control study of association between a candidate gene and a disease. In our approach, population substructure is detected and accounted for using data on additional loci that are in linkage equilibrium within subpopulations but have alleles that vary in frequency between subpopulations. We have tested our approach using simulated data based on allele frequencies in 12 short tandem repeat (STR) loci in four populations in Argentina.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1235279Documentos Relacionados
- Testing for Population Subdivision and Association in Four Case-Control Studies
- Regarding “Testing for Population Subdivision and Association in Four Case-Control Studies”
- Complexity and Power in Case-Control Association Studies
- Interval estimation of genetic susceptibility for retrospective case-control studies
- Bias in case-control studies. A review.