Accessory cholera enterotoxin (Ace), the third toxin of a Vibrio cholerae virulence cassette.
AUTOR(ES)
Trucksis, M
RESUMO
Vibrio cholerae causes the potentially lethal disease cholera through the elaboration of the intestinal secretogen cholera toxin. A second toxin of V. cholerae, Zot, decreases intestinal tissue resistance by modifying intercellular tight junctions. In this report, a third toxin of V. cholerae, Ace (accessory cholera enterotoxin), is described. Ace increases short-circuit current in Ussing chambers and causes fluid secretion in ligated rabbit ileal loops. The predicted protein sequence of Ace shows striking similarity to eukaryotic ion-transporting ATPases, including the product of the cystic fibrosis gene. The gene encoding Ace is located immediately upstream of the genes encoding Zot and cholera toxin. The ctx, zot, and ace genes, which are located on a dynamic sector of the chromosome, comprise a V. cholerae "virulence cassette."
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=46697Documentos Relacionados
- Production of Vibrio cholerae accessory cholera enterotoxin (Ace) in the yeast Pichia pastoris.
- Biochemistry of Vibrio cholerae virulence: purification of cholera enterotoxin by preparative disc electrophoresis.
- Biochemistry of Vibrio cholerae Virulence I. Purification and Biochemical Properties of PF/Cholera Enterotoxin
- Vibrio cholerae hemagglutinin/protease nicks cholera enterotoxin.
- Biochemistry of Vibrio cholerae Virulence II. Skin Permeability Factor/Cholera Enterotoxin Production in a Chemically Defined Medium
