Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications

AUTOR(ES)

Cardoso, B.A., Gírio, A., Henriques, C., Martins, L.R., Santos, C., Silva, A., Barata, J.T.

FONTE

Brazilian Journal of Medical and Biological Research

DATA DE PUBLICAÇÃO

30/04/2008

RESUMO

T-cell acute lymphoblastic leukemia (T-ALL) is a biologically heterogeneous disease with respect to phenotype, gene expression profile and activation of particular intracellular signaling pathways. Despite very significant improvements, current therapeutic regimens still fail to cure a portion of the patients and frequently implicate the use of aggressive protocols with long-term side effects. In this review, we focused on how deregulation of critical signaling pathways, in particular Notch, PI3K/Akt, MAPK, Jak/STAT and TGF-ß, may contribute to T-ALL. Identifying the alterations that affect intracellular pathways that regulate cell cycle and apoptosis is essential to understanding the biology of this malignancy, to define more effective markers for the correct stratification of patients into appropriate therapeutic regimens and to identify novel targets for the development of specific, less detrimental therapies for T-ALL.

Documentos Relacionados

• Subset derivation of T-cell acute lymphoblastic leukemia in man.
• Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia.
• High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
• T-cell large granular lymphocytic leukemia: treatment experience with fludarabine
• Mutações de PTEN nas leucemias linfóides agudas T