A Uropathogenicity Island Contributes to the Pathogenicity of Escherichia coli Strains That Cause Neonatal Meningitis

AUTOR(ES)

Houdouin, Véronique

FONTE

American Society for Microbiology

RESUMO

We report that the archetypal Escherichia coli strain C5 causing neonatal meningitis harbors a pathogenicity island (PAI) designated PAI IC5 that is similar to the PAI IIJ96 of uropathogenic E. coli J96 inserted in the leuX-tRNA gene. PAI-negative C5 mutants had a lower capacity than C5 to induce high-level bacteremia in a neonatal rat model. However, no change in their resistance to the bactericidal effect of serum and their capacity to cross the blood-brain barrier was observed.

Documentos Relacionados

• The Siderophore Receptor IroN, but Not the High-Pathogenicity Island or the Hemin Receptor ChuA, Contributes to the Bacteremic Step of Escherichia coli Neonatal Meningitis
• Prevalence of the “High-Pathogenicity Island” of Yersinia Species among Escherichia coli Strains That Are Pathogenic to Humans
• Yersinia High-Pathogenicity Island Contributes to Virulence in Escherichia coli Causing Extraintestinal Infections
• Characterization of an Anonymous Molecular Marker Strongly Linked to Escherichia coli Strains Causing Neonatal Meningitis
• Identification of Regions of the Escherichia coli Chromosome Specific for Neonatal Meningitis-Associated Strains