A transferable plasmid associated with AS-48 production in Enterococcus faecalis.
AUTOR(ES)
Martínez-Bueno, M
RESUMO
Enterococcus faecalis S-48 produces a peptide antibiotic, AS-48, and a bacteriocin, Bc-48. We have isolated mutants that lack these inhibitory characteristics. Further analysis of the mutants indicates that a plasmid of 56 kilobases (pMB2) may harbor the genes for AS-48. In conjugation experiments, pMB2 has been transferred into a plasmid-free OG1X strain of E. faecalis. The OG1X(pMB2) transconjugant produces the antibiotic AS-48 in solid medium, and the MIC of AS-48 for this strain is the same as that of the donor strain.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=208938Documentos Relacionados
- Effect of peptide AS-48 on Enterococcus faecalis subsp. liquefaciens S-47.
- Purification and amino acid composition of peptide antibiotic AS-48 produced by Streptococcus (Enterococcus) faecalis subsp. liquefaciens S-48.
- Characterization of a New Operon, as-48EFGH, from the as-48 Gene Cluster Involved in Immunity to Enterocin AS-48
- Chromosomally mediated beta-lactamase production and gentamicin resistance in Enterococcus faecalis.
- Tn5381, a conjugative transposon identifiable as a circular form in Enterococcus faecalis.
