A theory of allelic and isotypic exclusion for immunoglobulin genes.
AUTOR(ES)
Wabl, M
RESUMO
Heavy (H) chain binding protein (BiP), which binds to free immunoglobulin H chain of the mu and gamma classes, can be demonstrated in pre-B-cells. It is proposed that the displacement of BiP from H chain by light (L) chain terminates the activity of the enzyme system, L-generase, which catalyzes DNA rearrangement at the L chain loci, generating the complete gene which may or may not be functional. This ensures allelic and isotypic exclusion for the L chain loci. It is further proposed that those cells that productively rearrange both alleles at the H chain locus are eliminated by the "H chain toxicity" effect.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=347257Documentos Relacionados
- The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes.
- Comparison of different rearranged immunoglobulin kappa genes of a myeloma by electronmicroscopy and restriction mapping of cloned DNA: implications for "allelic exclusion".
- Transcription of mouse kappa chain genes: implications for allelic exclusion.
- Plasmacytomas with more than one immunoglobulin kappa mRNA: implications for allelic exclusion.
- Allelic exclusion of immunoglobulin expression is not caused by somatic segregation