A study of the distribution of phylogenetically conserved blocks within clusters of mammalian homeobox genes
AUTOR(ES)
Stojanovic, Nikola
FONTE
Genetics and Molecular Biology
DATA DE PUBLICAÇÃO
2009
RESUMO
Genome sequencing efforts of the last decade have produced a large amount of data, which has enabled whole-genome comparative analyses in order to locate potentially functional elements and study the overall patterns of phylogenetic conservation. In this paper we present a statistically based method for the characterization of these patterns in mammalian DNA sequences. We have applied this approach to the study of exceptionally well conserved homeobox gene clusters (Hox), based on an alignment of six species, and we have constructed a map of Hox cataloguing the conserved fragments, along with their locations in relation to the genes and other landmarks, sometimes showing unexpected layouts.
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