A spin label study of the effects of asbestos, quartz, and titanium dioxide dusts on the bovine erythrocyte membrane.

AUTOR(ES)

Leyko, W

RESUMO

The effects of five UICC asbestos samples, titanium dioxide, and quartz on the bovine red cell membrane have been studied in erythrocyte ghosts by the spin labelling technique. Analysis of the electron paramagnetic resonance (EPR) spectra of two sulphydryl reactive spin labels and one fatty acid spin label in red cell ghosts showed modifications in membrane protein after asbestos treatment but no alterations in membrane lipids. In experiments with quartz no membrane changes were noted but titanium dioxide altered the proteins bound with the protein reactive spin label used in the present study. The possible mechanism for these effects is discussed.

Documentos Relacionados

• Kinetics of the bronchoalveolar leucocyte response in rats during exposure to equal airborne mass concentrations of quartz, chrysotile asbestos, or titanium dioxide.
• A spin label study of the effect of chrysotile asbestos on erythrocyte membranes.
• Fracture-label:O cytochemistry of freeze-fracture faces in the erythrocyte membrane.
• Erythrocyte spectrin maintains its segmental motions on oxidation: a spin-label EPR study.
• Fibrogenic effect of wollastonite compared with asbestos dust and dusts containing quartz.