A simple square-wave voltammetric method for the determination of scopolamine in pharmaceuticals using a boron-doped diamond electrode

AUTOR(ES)

Santos, Simone Birkheur, Valezi, Camila Farinha, Scremin, Jessica, Salamanca-Neto, Carlos Alberto Rossi, Dall'Antonia, Luiz Henrique, Sartori, Elen Romão

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2014

RESUMO

A simple procedure is described for the determination of scopolamine by square-wave voltammetry using a cathodically pretreated boron-doped diamond electrode. Cyclic voltammetry studies indicate that the oxidation of scopolamine is irreversible at a peak potential of 1.59 V (vs. Ag/AgCl (3.0 mol L-1 KCl)) in a 0.50 mol L-1 sulfuric acid solution. Under optimized conditions, the analytical curve obtained was linear (r = 0.9996) for the scopolamine concentration range of 1.0 to 110 µmol L-1, with a detection limit of 0.84 µmol L-1. The method was successfully applied to the determination of scopolamine in pharmaceutical formulations with minimum sample preparation.

Documentos Relacionados

• Square-Wave Voltammetric Determination of Paracetamol and Codeine in Pharmaceutical and Human Body Fluid Samples Using a Cathodically Pretreated Boron-Doped Diamond Electrode
• Square-wave voltammetric determination of acetylsalicylic acid in pharmaceutical formulations using a boron-doped diamond electrode without the need of previous alkaline hydrolysis step
• Simultaneous Voltammetric Determination of Antihypertensive Drugs Amlodipine and Atenolol in Pharmaceuticals Using a Cathodically Pretreated Boron-Doped Diamond Electrode
• Voltammetric Determination of Ethionamide in Pharmaceutical Formulations and Human Urine using a Boron-Doped Diamond Electrode
• Determination of propylthiouracil in pharmaceuticals by differential pulse voltammetry using a cathodically pretreated boron-doped diamond electrode