A Serotyping Assay for Hepatitis C Virus in Southeast Asia

AUTOR(ES)

Songsivilai, Sirirurg

FONTE

American Society for Microbiology

RESUMO

A serotyping assay for hepatitis C virus (HCV) was evaluated with samples from Thailand, where the distribution of HCV genotypes was different from that in Western countries where the assay was designed and validated. The sensitivity of the assay was low (58%) for HCV RNA-positive samples compared to that of the genotyping assay (95%, P < 0.01). In addition, only 36% of anti-HCV-positive but HCV RNA-negative samples could be serotyped. The serotypes and genotypes were identical in 96% of the samples that could be typed by both methods. Most of the samples with genotype 6, which was common in Southeast Asia, were nontypeable by this serotyping assay.

Documentos Relacionados

• Survey of type 6 group variants of hepatitis C virus in Southeast Asia by using a core-based genotyping assay.
• Identification of a Novel Genotype of Hepatitis G Virus in Southeast Asia
• Evaluation of a New Serotyping Assay for Detection of Anti-Hepatitis C Virus Type-Specific Antibodies in Serum Samples
• Assessment of commercial enzyme immunoassay for hepatitis C virus serotyping.
• Origin and Evolution of Japanese Encephalitis Virus in Southeast Asia