A Role for Interleukin-6 in Host Defense against Murine Chlamydia trachomatis Infection

AUTOR(ES)

Williams, Dwight M.

FONTE

American Society for Microbiology

RESUMO

Interleukin-6-deficient (IL-6−/−) knockout mice had significantly increased Chlamydia trachomatis levels in lung tissue and increased mortality compared to B6129F2/J controls early after intranasal infection. Gamma interferon production and chlamydia-specific antibody levels were consistent with a decreased but reversible Th1-like response in IL-6−/− mice. IL-6 is needed for an optimal early host response to this infection.

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