A review of the epidemiology and treatment of Merkel cell carcinoma

AUTOR(ES)

Duprat, João Pedreira, Landman, Gilles, Salvajoli, João Victor, Brechtbühl, Eduard Rene

FONTE

Clinics

DATA DE PUBLICAÇÃO

2011

RESUMO

Merkel cell carcinoma is a very rare and aggressive neoplasm. Due to its rarity, therapeutic guidelines are not well established, especially for regionally advanced disease. Articles in English, French, Italian, Portuguese, and Spanish from the last 20 years were identified in MEDLINE and reviewed. The key word "Merkel" was used for the search, relevant articles were selected, and their references were examined. The most important articles related to epidemiology, genesis and treatment were reviewed. The incidence of Merkel cell carcinoma is increasing due to the advancing age of the population, higher rates of sun exposure and an increasing number of immunocompromised individuals. With regard to etiology, the recently described Merkel Cell polyomavirus is thought to play a role. Either local or regional surgical intervention remains the standard of care, but adjuvant radiotherapy or radiotherapy as a primary treatment have been discussed as reasonable therapeutic options. An update on this rare neoplasia is essential because of its increasing incidence and changing treatment options.

Documentos Relacionados

• Malignant melanoma after treatment for Merkel cell carcinoma,
• Evidence and Considerations on Treatment of Small Size Merkel Cell Head and Neck Carcinoma
• Sustained remission of metastatic Merkel cell carcinoma with treatment of HIV infection
• Surgical management of Merkel cell carcinoma.
• Merkel cell carcinoma: a malignant neuroendocrine tumour of the eyelid.