A Proposed Hydrogen Transfer Function for Cytochrome c

AUTOR(ES)

Harrison, John E.

RESUMO

Outlines of proposed mechanisms for cytochrome c oxidoreduction are presented which differ in detail from those previously published. The mechanisms, while accommodating the fact that cytochrome c is a net electron acceptor and donor in its catalytic cycle, dictate that the enzyme catalyses hydrogen transfer. It is shown that the mechanism of cytochrome c reduction fulfills a recent proposal that the transition state is an analogue of the structure of ferricytochrome c2. The implications of a hydrogen transfer role of cytochrome c are discussed.

Documentos Relacionados

• Intracellular gene transfer: Reduced hydrophobicity facilitates gene transfer for subunit 2 of cytochrome c oxidase
• Cytochrome c folding pathway: Kinetic native-state hydrogen exchange
• Crystallization of part of the mitochondrial electron transfer chain: cytochrome c oxidase--cytochrome c complex.
• A funneled energy landscape for cytochrome c directly predicts the sequential folding route inferred from hydrogen exchange experiments
• Cytochrome c oxidase: decay of the primary oxygen intermediate involves direct electron transfer from cytochrome a.